I used a C100 out of a Pelican 1510 for over 2 years. I would also have 4-5 lenses, a monitors, 2 lavs, no problem.
Can't see having any issues fitting both in there -> top handles will have to be removed for both though. (and obviously won't be able to fit 4-5 lenses)
I've fit 2 C100s in a single 1510 with the padded dividers, but you start to run out of space real quick when it comes to finding places for the handles, lenses and accessories.
Check out TrekPak dividers, I've fitted all my pelican cases with them. Nothing shy of amazing and extremely useful. Plus you don't have to hear the sound of velcro every time you need to change it around.
Second to TrekPak!! I have a set in a backpack and in a pelican case. Simple and efficient. A little pricey, but not if you travel often and need the most room, light weight, etc.