Nasality: How to minimize effect.

How much are you budgeted? I will try to remember which model exactly, but Blue Microphones makes a lot of mics that have very specialized emphases/frequency response curves, and one particular one was really great for a nasal voice at one point; it kind of scooped the midrange in a way that really worked well. It may have been a Dragonfly...

Otherwise, try a simple EQ to reduce frequencies around 1000 Hz as a starting point... sweep around between about 800 and 1400, and start with a wide Q, then narrow it down to "zoom in" on the problematic range...
 
The mic was an Octava MK-012, Cardioid capsule, about 2.5 feet in front of the Wife, just outside the frame top right corner.

Well, there's part of your problem. 2.5 feet is too much distance from subject to mic. Your effective working distance is really within 20", or closer depending on the room.

The extra room reflections are muddying up the sound and making it even more difficult to understand. That mud happens more in the low mids and lows. Also, lower frequencies curve a bit while higher frequencies travel in a much more direct manner, so depending on where the mic is and how it's aimed, it may be enhancing the lows of the direct sound and minimizing the higher frequencies. That, plus the distance, make for some pretty bad sound.

That frame is so tight that you could have the mic right on top of her and not see it. Try just in front of her (a couple if inches), and slightly overhead. It should be aimed at her sternum.
 
For a "physical fix", does anyone have any experience with having surgery to correct a deviated septum? Does it do anything to help alleviate a nasally voice?
 
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