Batutta
Major Contributor
Though I do think Star Trek more than most, used real science as a jumping off point, rather than just making up nonsense. Even the WARP drive, matter/anti-matter, in TNG things like the computer being housed in a subspace field so that it could perform faster than light calculations while in WARP(okay, subspace is bulls**t, but...). There's actually a pretty good book written by a physicist called "The Science of Star Trek" or something. He uses a lot of elements of the show to lead people into learning about real physics.
Yeah, I notice they do layer in small details you can speculate on so it doesn't come off as total BS. In TOS they even provided an explanation for why they encounter so many humanoid races in the galaxy. Sure, they real reason is that they didn't have the budget to do a new alien every week, but at least they cared enough to explain. This discussion reminded me of a talk Ron Moore gave about his exasperation with Star Trek tech and how that influenced BSG--
http://www.metacafe.com/watch/hl-50005879/blastr_ronald_d_moore_star_treks_tech_in_the_tech/