More and more voices come out indicating putting patients on ventilators is not helpful or even hurtful.
https://www.foxnews.com/health/docto...virus-pandemic
A testimonial by a doctor:
A new theory of what SAR-Cov-2 actually does indicates the primary issue is not the lungs but the transport of oxygen through hemoglobin. This is likely also the reason chloroquine can be helpful due to the fact that malaria interferes with hemoglobin as well.
https://www.dropbox.com/s/y1ssr1m68u...-9-EN.pdf?dl=0
"The study results show that ORF8 and surface glycoproteins could combine to the porphyrin
to form a complex, respectively. At the same time, orf1ab, ORF10, and ORF3a proteins could
coordinate attack the heme on the 1-beta chain of hemoglobin to dissociate the iron to form the
porphyrin. The attack will lead to less hemoglobin to carry oxygen and carbon dioxide. The lung cells
have extremely intense inflammation due to the inability to exchange carbon dioxide and oxygen
frequently, which eventually results in ground-glass-like lung images. Patients with respiratory distress
will be made worse. Diabetic patients and older people have higher glycated hemoglobin. Glycated
hemoglobin was reduced by the attack, which made patients' blood sugar unstable. Since the porphyrin
complexes of the virus produced in the human body inhibited the heme anabolic pathway, they caused
a wide range of infection and disease.
With these findings in mind, further analysis revealed that chloroquine could prevent orf1ab,
ORF3a, and ORF10 from attacking the heme to form the porphyrin, and inhibit the binding of ORF8
and surface glycoproteins to porphyrins to a certain extent, effectively relieve the symptoms of
respiratory distress. Since the ability of chloroquine to inhibit structural proteins is not particularly
obvious, the therapeutic effect on different people may be different. Favipiravir could inhibit the
envelope protein and ORF7a protein bind to porphyrin, prevent the virus from entering host cells, and
catching free porphyrins."
Thread: Coronavirus Impact II
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04-09-2020 04:44 PM
Last edited by Cary Knoop; 04-09-2020 at 05:02 PM.
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04-09-2020 05:04 PM
Trying to demonstrate"facts" and "statistics" in an environment where everything we think we know gets upended every three days, is not helpful. It's that type of stuff that leads us down the political hellhole, so how about we find something useful to talk about instead of repeating the same mistakes of the last three threads?
2 out of 3 members found this post helpful.
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04-09-2020 10:25 PM
Well, when the first post of the new thread "is hidden due to low votes. Click the arrow to the right to expand it."
it appears we may not be off to a good start and the thread lock gates may soon swing shut once again... ;)
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04-09-2020 10:58 PM
here's my contribution to the debate - things are so bad - I had to sack myself! NSFW
https://vimeo.com/405722894/338e80cae5
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04-10-2020 12:05 AM
Congrats! And double unemployment benefits!
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04-10-2020 01:12 PM
Older patients with comorbid conditions including hypertension have been associated with even higher mortality rates. The question arises, is this due to the high blood pressure or is it related to the medication?
There is a concern that ACE inhibitors (high blood pressure medicine) MAY have a negative impact on COVED19 infected patients.
https://jamanetwork.com/journals/jam...rticle/2763803
There is currently a clinical study ongoing that hopefully gives some answers to this concern:
https://clinicaltrials.gov/ct2/show/...draw=3&rank=11
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04-10-2020 01:30 PM
1 out of 2 members found this post helpful.
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04-10-2020 01:37 PM